×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
AlteredExpression
BEFREE
Thus, the present study suggests that activation of SRC is responsible for doxorubicin resistance in colon cancer .
29581735
2018
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
AlteredExpression
BEFREE
Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer .
28810597
2017
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
AlteredExpression
BEFREE
Cytoplasmic Localization of RUNX3 via Histone Deacetylase-Mediated SRC Expression in Oxidative-Stressed Colon Cancer Cells.
27990641
2017
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
Biomarker
BEFREE
These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer .
24714091
2014
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
Biomarker
BEFREE
Importantly, hyperactivation of SRC /EGFR signaling triggered by loss of PTPRO leads to high resistance of colon cancer to EGFR inhibitors.
25301722
2014
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
Biomarker
BEFREE
However, although Src protein is increased in colon cancer as early as the adenomatous polyp stage, a role for Src in carcinogenesis has not been established .
18351644
2008
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
Biomarker
BEFREE
Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro.
12820418
2003
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
GeneticVariation
BEFREE
However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising the hypothesis that the genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups.
11161376
2001
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
GeneticVariation
BEFREE
Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity.
10704743
2000
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
GeneticVariation
BEFREE
These results provide, for the first time, genetic evidence that activating SRC mutations may have a role in the malignant progression of human colon cancer .
9988270
1999
×
Entrez Id:
6714
Gene Symbol:
SRC
SRC
Colon Carcinoma
0.400
CausalMutation
CGI